Messages with an unreachable destination - Exch 2003 migration to Exch 2010

We are having issues with messages stuck in the queue folder Messages with an unreachable destination.  Also, some messages go through fine to an address one time, but another time the message will disappear.  They are not in junk folders.  I track the missing message and it says it was delivered to the Store.  I have rebooted several times.  Let me know if you need more info.  

We are in the early stages of the migration - no email boxes have been brought over to 2010.

TIA
HumongousAsked:
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HumongousAuthor Commented:
Additionally now, emails cannot be sent to external domains - no outgoing.
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SurajCommented:
A bit confused. What is the scenario. mail flow to external domain ?
i am asking inbound cos you say "delivered to the Store." so is it mail flow between 2003 and 2010?
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HumongousAuthor Commented:
It seems that there is an issue both inbound and outbound.  We are having a company do the migration for us.  There really should be no mail flow between the to Exchange boxes at this point.  EX: Some inbound emails from Sender1 reach their destination and show in the users Inbox - other inbound emails from Sender1 to the same user "disappear" even though tracking says it has been delivered properly.  I have tried w/ AV and AS products turned off, same results.

Outbound:  When I track a message sent by myself to an external address, it loops:
1. Message submitted from Store
2. Message submitted to Advanced queuing
3. Started message submission to advanced queue
4. ... submitted to Categorizer
5. ... categorized and queued for routing
6. ... routed and queued for remote delivery
*** End of loop 1 ***
Repeats messages 2 - 6


Make sense?
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HumongousAuthor Commented:
Perfect - thanks
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