machine.config file access issues

I receive the following error when I try and install an application from a web server.  I have changed permissions to the file and file location and I have have chnaged the ownership of the directory.  No of that resolves my issue.  This app works when I pog in ot the computer as an administrator, but it will not run when I log in as an average user.

PLATFORM VERSION INFO
      Windows                   : 6.1.7601.65536 (Win32NT)
      Common Language Runtime       : 4.0.30319.261
      System.Deployment.dll             : 4.0.30319.1 (RTMRel.030319-0100)
      clr.dll                   : 4.0.30319.261 (RTMGDR.030319-2600)
      dfdll.dll                   : 4.0.30319.1 (RTMRel.030319-0100)
      dfshim.dll                   : 4.0.31106.0 (Main.031106-0000)

SOURCES
      Deployment url                  : http://vm-ossirms/SunGard.PS.IJS.OS/SunGard.PS.IJS.OS.application

ERROR SUMMARY
      Below is a summary of the errors, details of these errors are listed later in the log.
      * Activation of http://vm-ossirms/SunGard.PS.IJS.OS/SunGard.PS.IJS.OS.application resulted in exception. Following failure messages were detected:
            + Configuration system failed to initialize
            + An error occurred loading a configuration file: Access to the path 'C:\Windows\Microsoft.NET\Framework\v4.0.30319\Config\machine.config' is denied. #C:\Windows\Microsoft.NET\Framework\v4.0.30319\Config\machine.config#
            + Access to the path 'C:\Windows\Microsoft.NET\Framework\v4.0.30319\Config\machine.config' is denied.

COMPONENT STORE TRANSACTION FAILURE SUMMARY
      No transaction error was detected.

WARNINGS
      There were no warnings during this operation.

OPERATION PROGRESS STATUS
      * [3/28/2012 11:35:31 AM] : Activation of http://vm-ossirms/SunGard.PS.IJS.OS/SunGard.PS.IJS.OS.application has started.

ERROR DETAILS
      Following errors were detected during this operation.
      * [3/28/2012 11:35:31 AM] System.Configuration.ConfigurationErrorsException
            - Configuration system failed to initialize
            - Source: System.Configuration
            - Stack trace:
                  at System.Configuration.ConfigurationManager.PrepareConfigSystem##
                  at System.Configuration.ConfigurationManager.GetSection#String sectionName#
                  at System.Configuration.PrivilegedConfigurationManager.GetSection#String sectionName#
                  at System.Net.Configuration.WebRequestModulesSectionInternal.GetSection##
                  at System.Net.WebRequest.get_PrefixList##
                  at System.Net.WebRequest.Create#Uri requestUri, Boolean useUriBase#
                  at System.Net.WebRequest.Create#Uri requestUri#
                  at System.Deployment.Application.SystemNetDownloader.DownloadSingleFile#DownloadQueueItem next#
                  at System.Deployment.Application.SystemNetDownloader.DownloadAllFiles##
                  at System.Deployment.Application.FileDownloader.Download#SubscriptionState subState#
                  at System.Deployment.Application.DownloadManager.DownloadManifestAsRawFile#Uri& sourceUri, String targetPath, IDownloadNotification notification, DownloadOptions options, ServerInformation& serverInformation#
                  at System.Deployment.Application.DownloadManager.DownloadDeploymentManifestDirectBypass#SubscriptionStore subStore, Uri& sourceUri, TempFile& tempFile, SubscriptionState& subState, IDownloadNotification notification, DownloadOptions options, ServerInformation& serverInformation#
                  at System.Deployment.Application.DownloadManager.DownloadDeploymentManifestBypass#SubscriptionStore subStore, Uri& sourceUri, TempFile& tempFile, SubscriptionState& subState, IDownloadNotification notification, DownloadOptions options#
                  at System.Deployment.Application.ApplicationActivator.PerformDeploymentActivation#Uri activationUri, Boolean isShortcut, String textualSubId, String deploymentProviderUrlFromExtension, BrowserSettings browserSettings, String& errorPageUrl#
                  at System.Deployment.Application.ApplicationActivator.ActivateDeploymentWorker#Object state#
            --- Inner Exception ---
            System.Configuration.ConfigurationErrorsException
            - An error occurred loading a configuration file: Access to the path 'C:\Windows\Microsoft.NET\Framework\v4.0.30319\Config\machine.config' is denied. #C:\Windows\Microsoft.NET\Framework\v4.0.30319\Config\machine.config#
            - Source: System.Configuration
            - Stack trace:
                  at System.Configuration.ConfigurationSchemaErrors.ThrowIfErrors#Boolean ignoreLocal#
                  at System.Configuration.BaseConfigurationRecord.ThrowIfParseErrors#ConfigurationSchemaErrors schemaErrors#
                  at System.Configuration.BaseConfigurationRecord.ThrowIfInitErrors##
                  at System.Configuration.ClientConfigurationSystem.EnsureInit#String configKey#
            --- Inner Exception ---
            System.UnauthorizedAccessException
            - Access to the path 'C:\Windows\Microsoft.NET\Framework\v4.0.30319\Config\machine.config' is denied.
            - Source: mscorlib
            - Stack trace:
                  at System.IO.__Error.WinIOError#Int32 errorCode, String maybeFullPath#
                  at System.IO.FileStream.Init#String path, FileMode mode, FileAccess access, Int32 rights, Boolean useRights, FileShare share, Int32 bufferSize, FileOptions options, SECURITY_ATTRIBUTES secAttrs, String msgPath, Boolean bFromProxy, Boolean useLongPath#
                  at System.IO.FileStream..ctor#String path, FileMode mode, FileAccess access, FileShare share#
                  at System.Configuration.Internal.InternalConfigHost.StaticOpenStreamForRead#String streamName#
                  at System.Configuration.Internal.InternalConfigHost.System.Configuration.Internal.IInternalConfigHost.OpenStreamForRead#String streamName, Boolean assertPermissions#
                  at System.Configuration.Internal.InternalConfigHost.System.Configuration.Internal.IInternalConfigHost.OpenStreamForRead#String streamName#
                  at System.Configuration.ClientConfigurationHost.OpenStreamForRead#String streamName#
                  at System.Configuration.BaseConfigurationRecord.InitConfigFromFile##

COMPONENT STORE TRANSACTION DETAILS
      No transaction information is available.
MariettaMISAsked:
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