IIS .NET upgrade

I have a new DLL called from an ASPX page.
Getting this error:

This assembly is built by a runtime newer than the currently loaded runtime and cannot be loaded
Version Information: Microsoft .NET Framework Version:2.0.50727.3623; ASP.NET Version:2.0.50727.3618

So I installed .NET 4.0
Restarted  webserver

.NET 4.0 shows up in  ISAPI filters.

What do I have to do to get it to use 4.0?
Have not rebooted the server, as it did not require or suggest after the  .NET install.
awalkintheparkAsked:
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Dave BaldwinFixer of ProblemsCommented:
I'd reboot.  I usually do it just because when I install anything from Microsoft.
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awalkintheparkAuthor Commented:
Just tried it, same result
the error message still shows:
Version Information: Microsoft .NET Framework Version:2.0.50727.3623; ASP.NET Version:2.0.50727.3618
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awalkintheparkAuthor Commented:
That's it.  Thanks.
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