After looking through all of the Google searches on splitting up the CAS/HUB roles post install, I went ahead and installed a new CAS server in our environment called EXCH-CAS-01 (Hub is EXCH-HUB-01).
At the same time, I decided it was time to change our OWA, ActiveSync, and Auto Discover URLs to match our new company name and domain. I've generated a certificate for the new domain name and installed it on the new CAS server.
A few issues that I've run into.
Outlook 2010 no longer provides Mail Tips, if you setup an ActiveSync device with the new server address, the device receives messages, but will not fully download them, and a number of users using Outlook Anywhere cannot connect to the server.