SBS 2003 Backup Failing Periodically

I have a client with a SBS 2003 server.  Recently the backups have been failing periodically with the following error message...

"Error: Could not access portions of directory System State\Registry.
You may not have permission to open the file, or the directory may be missing or damaged.
Please contact the owner or administrator."

and then...

"NTBackup finished the backup with errors."

This error has started occuring about 50% of the time and does NOT seem to occur only when a paritcular external hard drive is hooked up for that nights backup.

Any help is appreciated.  Thank you.
lcstech1Asked:
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Randy DownsOWNERCommented:
Maybe this will help

http://forums.techarena.in/small-business-server/400178.htm

We have seen some issue that backup users has no permission to access
COM+ Class Registration Database and it proved to be the third party
applications, such as some Open File Manager Service. So please check it on
the SBS Server to see if it is installed. If it is, uninstall it and try
again to see how everything is going.
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Randy DownsOWNERCommented:
Some more possibilities here

http://us.generation-nt.com/answer/sbs-2003-backup-help-139299801.html

check your AV software and make sure you've
properly configured exclusions properly

I
would like to suggest that you check the following steps:

1. Clean boot.
A Clean Boot will allow us to isolate any programs that are loading at
startup that may be causing a conflict with other device drivers or
programs that are installed in your computer.

1) Run MSCONFIG.EXE. (MSCONFIG is a built-in tool for Windows XP\2003
systems.)

2) In the Services tab, click "Hide All Microsoft Services" and click
"Disable All". Please note that the Exchange services could be marked as
non-Microsoft. Please do not disable those services.

3) In the Startup tab, click "Disable All". Click OK. (This will
temporarily prevent third-party programs from running automatically during
start-up.)

4) Restart the computer. Does the problem still persist?

If the problem does not occur, it indicates that the problem is related to
one application or service we have disabled. You can use the MSCONFIG tool
again to re-enable the disabled item one by one to find out the culprit.

2. If you are using external hard drive, please check whether the USB
interface support USB 2.0. If possible, please try to find a PCI USB
adapter which support USB 2.0, connect the external hard drive to it and
test again. Also you may like backup to internal hard drive directly as a
test.

3. Run the command: chkdsk /F on the external drive to make sure it works
fine.

4. To remove the CD from the CD ROM drive and take a back up.

5. Try to remove IBM's Tivoli TSM if it was installed.
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