Several queues in Exchange 2010 error 451 4.4.0

I have several domains that keep trying to retry with no luck as the mail messages keep piling up in the queue. The all have the same error message 451 4.4.0 Primary target IP address responded with: "421 4.4.2 connection dropped due to socket error. Attempted failover to alternate host, but did not succeed.

Please some help would be appreciated.
natevelli2Asked:
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Alan HardistyCo-OwnerCommented:
Please have a read of my article and check you don't have any obvious configuration / blacklisting problems:

http://www.experts-exchange.com/Software/Server_Software/Email_Servers/A_2427-Problems-sending-mail-to-one-or-more-external-domains.html

If you do - what are they?
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natevelli2Author Commented:
Good on blacklist, DNS reverse lookup for mail server is setup, have a sonic firewall ns 240 and dont see anything out of the ordinary there.
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Alan HardistyCo-OwnerCommented:
Have you got SMTP Inspection enabled on your Sonicwall?
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natevelli2Author Commented:
I do not see anything for smtp inspection on my firewall. Where should I look?
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Alan HardistyCo-OwnerCommented:
Try the following (I don't know the SonicWall range, but know about the problems when using them):

Security Services > Gateway Anti-Virus page.  Is SMTP inbound or Outbound enabled?

(Extracted from Page 46 -  http://www.sonicwall.com/downloads/SonicWALL_NSA_240_Getting_Started_Guide.pdf)
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natevelli2Author Commented:
I disabled smtp in and outbound with no luck.
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natevelli2Author Commented:
After a bunch of back and forths it finally ended up being the recieving side using SORBS and our ISP using dynamic IPs
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Alan HardistyCo-OwnerCommented:
Just curious as to why the solution seems to be that you were blacklisted yet my comment http:#a37840409 which suggests you check there are no obvious blacklisting issues wasn't included as part of the solution.

Alan
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