troubleshooting Question

EXCHANGE PROBLEM 451 4.4.0 Primary Target IP address responded 421 4.2.1 unable to connect

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I have a Exchange Server 2010 on a Windows Server 2008 X64.
Everything was good but since once week i have message not delivery ton my client.
In the exchange manager console i can see this error:

451 4.4.0 Primary Target IP address responded 421 4.2.1 unable to connect. Attempted failover to the alternate host but That did not succeed. Either, there are ni alternate hosts, or delivery failed to all alternate hosts

I have an other send connector and i have the differents domains with trouble inside.
I used the

With some domains, i have no problem.

Could you help me?

NB: Sorry for my English I'm not so good --> (French Speaking)

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