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None that I have experienced.
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Well we already use it. - I should have maybe explained in more detail....<br />
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I was thinking of using it for the migration of 2003 - 2008 but now will use FSMT and crate new DFS namespaces on 2k8 boxes and replicate as we do now.
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Planning on using 2003 and 2008 r2 for local replication of namespaces etc.<br />
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Any issues people are aware of?
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Planning on using 2003 and 2008 r2 for local replication of namespaces etc.

Any issues people are aware of?

DFS Replication

Windows Server 2008 and Windows Server 2008 R2, based on the Microsoft Vista codebase, is the last 32-bit server operating system released by Microsoft. It has a number of versions, including including Foundation, Standard, Enterprise, Datacenter, Web, HPC Server, Itanium and Storage; new features included server core installation and Hyper-V.

Windows Server 2008

Windows Server 2003 was based on Windows XP and was released in four editions: Web, Standard, Enterprise and Datacenter. It also had derivative versions for clusters, storage and Microsoft’s Small Business Server. Important upgrades included integrating Internet Information Services (IIS), improvements to Active Directory (AD) and Group Policy (GP), and the migration to Automated System Recovery (ASR).

Windows Server 2003

Active Directory (AD) is a Microsoft brand for identity-related capabilities. In the on-premises world, Windows Server AD provides a set of identity capabilities and services, and is hugely popular (88% of Fortune 1000 and 95% of enterprises use AD). This topic includes all things Active Directory including DNS, Group Policy, DFS, troubleshooting, ADFS, and all other topics under the Microsoft AD and identity umbrella.