Server 2008 - access denied on local drive

I have a local data drive E: on my 2008Server, which I have been accessing for a couple of years with no problem. The last few weeks it periodically gives me a message "Access Denied", when I try to access the drive as the administrator. If I reboot the server the problem goes away, and it also sometime goes away by itself. The sever is running in a RAID5 configuration with 2 logical disk drives (C: for programs and e: for data).

Any help would be appreciated.
IrvingGAsked:
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IrvingGConnect With a Mentor Author Commented:
Thanks for info. Seems I was running a Image backup on the C: drive of the server and that caused the E: to inaccessible.
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MikeIT ManagerCommented:
I've had this happen to me before, but it was folders.  After months of troubleshooting and trying various different fixes/workarounds, we would up formatting the OS partition, reinstalling, and then setting the correct permissions for folders we couldn't access.  Solved the problem for us.
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Will SzymkowskiSenior Solution ArchitectCommented:
When you run into this error message have you checked the Event Viewer to see if there are any issues listed in there, possible service of some sort stopped? Have you also tried to run sfc /scannow to check and see if the Windows Core file system is not corrupted in anyway?
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Seth SimmonsSr. Systems AdministratorCommented:
This question has been classified as abandoned and is closed as part of the Cleanup Program. See the recommendation for more details.
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