Out of Office issues after exchange upgrade from SBS 2003 to 2010 Std

I am having an issue with Out of Office working intermittently after upgrading from Exchange integrated SBS 2003 to Exchange 2010.  It works some of the time and other times users get a popup stating it is unable to configure.  Not positive exact term at the moment.  One thing we had to do was delete the existing SSL Certificate which were associated with the migration and create new.  The existing one were not issued by a CA.  The new ones are self-signed.  After creating the certs, features like OWA began working again.  We think it is an issue with IIS but not sure where.

Thanks in advance.
ssiremoteAsked:
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Manpreet SIngh KhatraConnect With a Mentor Solutions Architect, Project LeadCommented:
Do you see any events logged for IIS or CAS related in the App log on the server ?
out-of-office works with Autodiscover so your DNS should also be in good health for it to work efficiently.

- Rancy
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craigp81Commented:
What is the error message?  This sometimes happens at the company where I work. You can get as far as creating the OOO message but an error pops up when you try to apply. Not sure of the error off of the top of my head but disabling used cached logon within the outlook email properties resolves it.
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