Guys, I have Citrix PS 4 (yeah still using it ) on Windows 2003. Few weeks ago I had maintenance on all of our servers apply MS Windows security updates.
After the updates were applied no problem but after the scheduled reboot of Citrix users are getting "I am unable to open citrix, I get the following error message: Unable to launch your application. Contact your help desk with the following information: Cannot connect to the Citrix XenApp server. Protocol Driver error"
I had to redo some of the security permission for Ctx_SmaUser and follow the steps from the link below to reset the ICA 3.0 to use a specific NIC. Reboot after these changes and it worked fine - reboot again and I get the same protocol error above again. Reboot few more and it work fine without any change. Changing the ICA to use the server NIC or use all NIC doesn't seem to make a difference here.
Since then I have deleted the old Citrix ICA and created new ICA but still the same problem after a reboot. I did noticed that in the registry the old deleted ICA was created under the Console section vs new ICA under WinStations (pic attached) - just FYI.
Assigning ICA-tcp properties to a specific network adapter - not working