.net breakpoints not being hit - No symbols loaded

It appears I've been struck with the infamous "no symbols loaded" bug with VS2005. The project was working until recently and I noticed that my breakpoint inside an AJAX function was not being hit. Javascript breakpoints are working, but .net breakpoints are not. I've spent countless hours on the net looking for solutions, and everyone seems to have something different that worked for them. I've tried most of them, but nothing is working. If I recall, I have:
iisrest
deleted asp.net temp files - verified pdb files exist after recompile
ensured debug=true in web.config
reset IE settings
detached/reattached IE in debugger processes
loaded the project into a new folder from vault
other stuff I cant remember...

Running Win XP, VS 2005 and the project is vb.net v2. The text below is the output from a compile. I'm not worried about the just my code lines, but the no symbols loaded lines have got to be the issue. If anyone can suggest something that will prevent my banging my head against the desk, I'd appreciate.


Auto-attach to process '[364] aspnet_wp.exe' on machine 'OP320_06' succeeded.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\assembly\GAC_32\mscorlib\2.0.0.0__b77a5c561934e089\mscorlib.dll', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\assembly\GAC_32\System.Web\2.0.0.0__b03f5f7f11d50a3a\System.Web.dll', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\assembly\GAC_MSIL\System\2.0.0.0__b77a5c561934e089\System.dll', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\assembly\GAC_MSIL\System.Configuration\2.0.0.0__b03f5f7f11d50a3a\System.Configuration.dll', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\assembly\GAC_MSIL\System.Xml\2.0.0.0__b77a5c561934e089\System.Xml.dll', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\assembly\GAC_MSIL\Microsoft.JScript\8.0.0.0__b03f5f7f11d50a3a\Microsoft.JScript.dll', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\assembly\GAC_32\VJSharpCodeProvider\2.0.0.0__b03f5f7f11d50a3a\VJSharpCodeProvider.dll', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\assembly\GAC_MSIL\CppCodeProvider\8.0.0.0__b03f5f7f11d50a3a\CppCodeProvider.dll', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\Microsoft.NET\Framework\v2.0.50727\Temporary ASP.NET Files\root\721c6ad4\8e128578\App_Code.cevz69g1.dll', No symbols loaded.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\assembly\GAC_MSIL\Microsoft.VisualBasic\8.0.0.0__b03f5f7f11d50a3a\Microsoft.VisualBasic.dll', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\assembly\GAC_32\System.Data\2.0.0.0__b77a5c561934e089\System.Data.dll', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\assembly\GAC_MSIL\System.Web.Services\2.0.0.0__b03f5f7f11d50a3a\System.Web.Services.dll', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\assembly\GAC_MSIL\System.Web.Extensions\1.0.61025.0__31bf3856ad364e35\System.Web.Extensions.dll', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\Microsoft.NET\Framework\v2.0.50727\Temporary ASP.NET Files\root\721c6ad4\8e128578\assembly\dl3\34259e3b\497b0d6a_40c8c901\log4net.DLL', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\Microsoft.NET\Framework\v2.0.50727\Temporary ASP.NET Files\root\721c6ad4\8e128578\assembly\dl3\c6481bef\896ea597_95a9ca01\UPS_AV.DLL', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\Microsoft.NET\Framework\v2.0.50727\Temporary ASP.NET Files\root\721c6ad4\8e128578\assembly\dl3\8419a6a5\18fb6bb0_954bcb01\Antlr.TaskParser.DLL', No symbols loaded.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\Microsoft.NET\Framework\v2.0.50727\Temporary ASP.NET Files\root\721c6ad4\8e128578\assembly\dl3\52a3048c\11c2e06b_40c8c901\DataProtection.DLL', No symbols loaded.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\Microsoft.NET\Framework\v2.0.50727\Temporary ASP.NET Files\root\721c6ad4\8e128578\assembly\dl3\ebdb6845\69a0336a_40c8c901\Encrypt.DLL', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\assembly\GAC_MSIL\System.DirectoryServices\2.0.0.0__b03f5f7f11d50a3a\System.DirectoryServices.dll', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\Microsoft.NET\Framework\v2.0.50727\Temporary ASP.NET Files\root\721c6ad4\8e128578\App_global.asax.re5c1nan.dll', No symbols loaded.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\Microsoft.NET\Framework\v2.0.50727\Temporary ASP.NET Files\root\721c6ad4\8e128578\App_Browsers.4e1aehlw.dll', No symbols loaded.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\assembly\GAC_MSIL\System.Web.Mobile\2.0.0.0__b03f5f7f11d50a3a\System.Web.Mobile.dll', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\assembly\GAC_MSIL\System.ServiceModel\3.0.0.0__b77a5c561934e089\System.ServiceModel.dll', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\Microsoft.NET\Framework\v2.0.50727\Temporary ASP.NET Files\root\721c6ad4\8e128578\assembly\dl3\d869de0c\b1293d6a_40c8c901\Intelligencia.UrlRewriter.DLL', No symbols loaded.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\Microsoft.NET\Framework\v2.0.50727\Temporary ASP.NET Files\root\721c6ad4\8e128578\assembly\dl3\c0f5f8b2\9d774b6a_40c8c901\WebPageSecurity.DLL', No symbols loaded.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\assembly\GAC_MSIL\SMDiagnostics\3.0.0.0__b77a5c561934e089\SMDiagnostics.dll', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\Microsoft.NET\Framework\v2.0.50727\Temporary ASP.NET Files\root\721c6ad4\8e128578\assembly\dl3\08690991\7d52256a_40c8c901\Newtonsoft.Sitemaps.DLL', No symbols loaded.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\Microsoft.NET\Framework\v2.0.50727\Temporary ASP.NET Files\root\721c6ad4\8e128578\App_Web_index.aspx.cdcab7d2.vwvmjtpt.dll', No symbols loaded.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\Microsoft.NET\Framework\v2.0.50727\Temporary ASP.NET Files\root\721c6ad4\8e128578\App_Web_main.master.cdcab7d2.syho40pe.dll', No symbols loaded.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\Microsoft.NET\Framework\v2.0.50727\Temporary ASP.NET Files\root\721c6ad4\8e128578\assembly\dl3\ecaeafd3\001a471d_b8b5cb01\Telerik.Web.UI.DLL', No symbols loaded.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\Microsoft.NET\Framework\v2.0.50727\Temporary ASP.NET Files\root\721c6ad4\8e128578\assembly\dl3\5b4a39da\00178238_c62ac801\AjaxControlToolkit.DLL', No symbols loaded.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\assembly\GAC_MSIL\System.Web.RegularExpressions\2.0.0.0__b03f5f7f11d50a3a\System.Web.RegularExpressions.dll', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\assembly\GAC_MSIL\System.Drawing\2.0.0.0__b03f5f7f11d50a3a\System.Drawing.dll', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
'aspnet_wp.exe' (Managed): Loaded 'A_9be5a2ee_6351_4a7e_b040_ecd84ee08367', No symbols loaded.
'aspnet_wp.exe' (Managed): Loaded 'M_9be5a2ee_6351_4a7e_b040_ecd84ee08367', No symbols loaded.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\assembly\GAC_32\System.Transactions\2.0.0.0__b77a5c561934e089\System.Transactions.dll', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\assembly\GAC_32\System.EnterpriseServices\2.0.0.0__b03f5f7f11d50a3a\System.EnterpriseServices.dll', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
'aspnet_wp.exe' (Managed): Loaded 'C:\WINDOWS\assembly\GAC_MSIL\System.Design\2.0.0.0__b03f5f7f11d50a3a\System.Design.dll', Skipped loading symbols. Module is optimized and the debugger option 'Just My Code' is enabled.
The thread 'Thread EC0' (0xec0) has exited with code 0 (0x0).
The program '[2136] iexplore.exe: Script program' has exited with code 0 (0x0).
The program '[364] aspnet_wp.exe: Managed' has exited with code 0 (0x0).

nzinsliAsked:
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nzinsliAuthor Commented:
Ended up doing a clean XP install.
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Jacques Bourgeois (James Burger)PresidentCommented:
Having the .pdb after compile is not enough. They can be from an older compilation. If the .pdb you see in the compile directory do not have the date and time of compilation, then the option to generate .pdb in the Project's properties has been deactivated.
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nzinsliAuthor Commented:
The pdbs appeared after I cleared the asp.net temp files folder, so I can be sure they were from the compile that I ran after deleting the folder.
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nzinsliAuthor Commented:
Wasted another day on Google yesterday. Anyone have an idea?
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nzinsliAuthor Commented:
Had to format to fix
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