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I have not tried yet, but it seems it is possible:<br />
<a href="http://greghurlman.com/2011/05/16/monotouch-for-visual-studio-2010/" rel="ugc">http://greghurlman.com/2011/05/16/monotouch-for-visual-studio-2010/</a><br />
<a href="http://blog.manniat.net/post/2009/11/18/MonoTouch-in-Visual-Studio.aspx" rel="ugc">http://blog.manniat.net/post/2009/11/18/MonoTouch-in-Visual-Studio.aspx</a><br />
<a href="https://github.com/jamiebriant/VsMono" rel="ugc">https://github.com/jamiebriant/VsMono</a>
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I have not tried yet, but it seems it is possible:
http://greghurlman.com/2011/05/16/monotouch-for-visual-studio-2010/ [http://greghurlman.com/2011/05/16/monotouch-for-visual-studio-2010/]
http://blog.manniat.net/post/2009/11/18/MonoTouch-in-Visual-Studio.aspx [http://blog.manniat.net/post/2009/11/18/MonoTouch-in-Visual-Studio.aspx]
https://github.com/jamiebriant/VsMono [https://github.com/jamiebriant/VsMono]

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No you need a mac, Apples decision
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Is there a way of developing for the iPhone in VS2010 on the PC?
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Is there a way of developing for the iPhone in VS2010 on the PC?

Mono Touch + Development for VS2010

The .NET Framework is not specific to any one programming language; rather, it includes a library of functions that allows developers to rapidly build applications. Several supported languages include C#, VB.NET, C++ or ASP.NET.

.NET Programming

Mobile web development, also known as responsive web design, is an approach to web design aimed at crafting sites to provide an optimal viewing and interaction experience—easy reading and navigation with a minimum of resizing, panning, and scrolling—across a wide range of devices (from desktop computer monitors to mobile phones). A site designed with RWD adapts the layout to the viewing environment by using fluid, proportion-based grids, flexible images, and CSS3 media queries.

Responsive Web

The iPhone is a smartphone made by Apple Inc. It and the iPad, along with several other mobile devices from Apple, run on the iOS operating system, which has its own topic, as does the iPad for device-specific questions. Native iOS applications are written in Objective-C or in Swift using the Cocoa Touch frameworks or HTML5 compiled with the help of a package manager such as Adobe PhoneGap; a common IDE is Xcode.

iPhone

Mono is an open source platform based on the .NET framework to enable the development of Linux and other cross-platform applications. Based on C# and the Common Language Infrastructure (CLI) standards, applications can also be developed in VB.NET, Java, Python, F#, Ruby, Eiffel and others, and includes a Microsoft compatible API.