Best Practice for Creating Additional Sites in Drupal?

I've installed a local WAMP stack for Drupal test and development.

My default site is "Site-A".

Going foward, I want to develop new sites, no relation to each other.

Do I simply create a directory "Site-B" in the Sites folder?

Then access like  http://localhost/sites/Site-B   ?

What's the best practice for creating several sites in the same Drupal installation ?
Who is Participating?
Aaron FeledyDrupal Developer and ConsultantCommented:
Take a look at example.sites.php located in the sites folder. It explains how to set up the multi site aliasing feature using a sites.php file. After you set it up, you'll be able to do something like http://localhost/Site-B to access your site.
That really depends on what are the inter relations between these sites:
Watch this video for a better understanding of the different approaches.
Here you'll find a lot of information about multisites.
Watch Emma Jane Hogbin's video for a deeper dive..
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