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There is no such thing as &quot;what is the best&quot; in this scenario.<br />
<br />
It does completely depend on how your users interact with your site. There is nothing wrong with your set up (and I'm assuming you meant Nginx for as a reverse-proxy page cache for auth'ed users).<br />
<br />
Is there something your current architecture is not satisfying?
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There is no such thing as "what is the best" in this scenario.

It does completely depend on how your users interact with your site. There is nothing wrong with your set up (and I'm assuming you meant Nginx for as a reverse-proxy page cache for auth'ed users).

Is there something your current architecture is not satisfying?

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Yes the pages load time is too slow and i have 50 users accessing every min<br />
And the server is a 4 core with 6 Gb ram
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Yes the pages load time is too slow and i have 50 users accessing every min
And the server is a 4 core with 6 Gb ram

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Are you using Drupal 6 or 7? Drupal 7 is much faster.
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Are you using Drupal 6 or 7? Drupal 7 is much faster.

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<div class="content wysiwyg-content">
What is the best caching mechanism for a drupal website<br />
<br />
We currently have memcache for NON logged in members and Nqix for members who are logged into the site<br />
<br />
Is their a better option?
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What is the best caching mechanism for a drupal website

We currently have memcache for NON logged in members and Nqix for members who are logged into the site

Is their a better option?

What is the best caching mechanism for a drupal website

Drupal is an open-source content-management framework written in PHP used as a back-end framework for websites and is also used for knowledge management and business collaboration. The standard release of Drupal contains basic features common to content management systems, including user account registration and maintenance, menu management, RSS feeds, taxonomy, page layout customization, and system administration. Drupal runs on any computing platform that supports both a Web server capable of running PHP and a database to store content and configuration.

Drupal

Content management (CM) is a set of processes and technologies that supports the collection, managing, and publishing of information in any form or medium. When stored and accessed via computers, this information may be more specifically referred to as digital content, or simply as content. Digital content may take the form of text (such as electronic documents), multimedia files (such as audio or video files), or any other file type that follows a content lifecycle requiring management.

Content Management

PHP is a widely-used server-side scripting language especially suited for web development, powering tens of millions of sites from Facebook to personal WordPress blogs. PHP is often paired with the MySQL relational database, but includes support for most other mainstream databases. By utilizing different Server APIs, PHP can work on many different web servers as a server-side scripting language.