trouble with POP3 account

We have an Exchange 2003 mailbox that the user is connecting to through a POP3 Outlook 2007 client and pulling his and pushing his email, and he's getting various results with it.  For example, some email comes back saying "550 5.7.1 Unable to relay for [address]". Another email came back saying "Email account doesn't exist at organization", when I know that they do, and have sent to the very same recipient from other corporate mailboxes (not via POP).  But - some email works, and sends successfully from this mailbox.  So - not sure what's wrong with the configuration, and could use some advice.

thanks
Damian_GardnerAsked:
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Damian_GardnerAuthor Commented:
to add to this...it appears there could be something about some of the new email account users we've setup on our Exchange server (we acquired another comapny and inherited users) - I've just noticed that if I send to one of the new users from outside the corporate network, the email is successfully delivered. But if I try to send to the user from an internal mailbox, Exchange bounces it back!  error is "email does not exist".  this is very strange...
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wolfcamelConnect With a Mentor Commented:
sometimes these messages are generated by the antispam at the receipient.

Is he sending via your exchange server or via a different SMTP server?
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Damian_GardnerAuthor Commented:
It's via the same Exchange server.
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Damian_GardnerAuthor Commented:
it looks like it's a bad autonameing cached address that's atleast causing the problem with one address...
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imkotteesSenior Messaging EngineerCommented:
Yes, for me also looks problem with caching.. delete the old cache.. select the user from GAL and send mail..

for acquired company there might be some problem with smtp config. please double check them.
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Damian_GardnerAuthor Commented:
So - this solves one of the problems, which is the unrecognized user issue.  but doesn't explain the relaying issue.
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Damian_GardnerAuthor Commented:
Well - I was able to resolve it by setting the configuration to log on to the server BEFORE sending, through the "Outgoing Server" config tab in the profile.  Thanks for help.
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