A user since last Thursday cannot access RWW or OWA and is being faced with "Internet Explorer Cannot Display the Webpage"
You can work around this by running as administrator. Unfortunately, I cannot set this in the shortcut properties.
Firefox runs fine as well.
I am assuming IE, run as a normal user, cannot access the trusted certificate which is in the Trusted Root Certification Authorities store.
I have tried removing certificates and reimporting but this has not worked.