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I've requested that this question be deleted for the following reason:<br />
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Problem solved, firewall was blocking outbound web traffic. 
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I've requested that this question be deleted for the following reason:

Problem solved, firewall was blocking outbound web traffic.

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it will works if isa down now question how<br />
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you should identify dns setting on cisco router and as you mentioned the gateway is ur router it means that cisco provided internet traffic in case of tmg failure you can easily divert your ur client toward to use internet but you need to mentioned dns of cisco router on client machine.<br />
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Regards,<br />
Osama Mansoor
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it will works if isa down now question how

you should identify dns setting on cisco router and as you mentioned the gateway is ur router it means that cisco provided internet traffic in case of tmg failure you can easily divert your ur client toward to use internet but you need to mentioned dns of cisco router on client machine.

Regards,
Osama Mansoor

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Yes, I would object based on my comment to you above.
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Yes, I would object based on my comment to you above.

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We have a pretty standard Windows network setup here. Windows 2008R2 AD, DNS, etc.<br />
<br />
I also have an ISA 2006 server setup in single adapter mode, it has web filtering software installed, that's all it's really used for. It only has 1 nic.<br />
<br />
Clients default gateway points to our Cisco router. Browsers have proxy settings pointing to the ISA server, and all works well.<br />
<br />
In IE if I uncheck &quot;Use a proxy server...&quot; I am unable to get online. What if our ISA server goes down, or I want to remove it from the network?? Clients will be unable to get online?<br />
<br />
Any help would be greatly appreciated, thanks.
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We have a pretty standard Windows network setup here. Windows 2008R2 AD, DNS, etc.

I also have an ISA 2006 server setup in single adapter mode, it has web filtering software installed, that's all it's really used for. It only has 1 nic.

Clients default gateway points to our Cisco router. Browsers have proxy settings pointing to the ISA server, and all works well.

In IE if I uncheck "Use a proxy server..." I am unable to get online. What if our ISA server goes down, or I want to remove it from the network?? Clients will be unable to get online?

Any help would be greatly appreciated, thanks.

bypass ISA 2006, no internet

Microsoft Forefront, formerly known as Internet Security and Acceleration Server (ISA Server), is a network router, firewall, antivirus program, VPN server and web cache that runs on Windows servers. It includes identity management and protection systems, and discontinued systems for threat management and network protection, along with protection for Sharepoint and Exchange. The scope of discussions includes forward and reverse proxy, application and service publishing, virtual private networks (VPNs), outbound access rules, SSL certificates and network routing within either a single node or an highly-available array pairing.