Mouse slow to responde

I've been having this problem for a while now where the mouse movement response is slow on and off.

I can reboot the computer and it make no differents. From time to time I notice that Explorer stops responding and then my task bar disappears and come back up when Explorer is restarted.  

At first I replaced the mouse with a new one but that did not help. I usually have 10-20 windows open (multiple RDP sessions, Access, Word, Excel, two different ERP applications, Crystal Reports, Chrome, FireFox, IE VMware Workstation, etc...).

Computer Specs
Intel Core i7 CPU 870 2.93 GHz
16 GB of Ram
1 TB RAID 0 (2 sata drives)
Windows 7

Any ideas where to start with troubleshooting?
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GerhardpetAsked:
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GerhardpetConnect With a Mentor Author Commented:
No that is not the case. I can reboot the computer with nothing open and it will do it too. Again totally random.
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vastoCommented:
Check the processor usage in Task Manager. You may have a process , which is taking a big percentage of the processor time.
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GerhardpetAuthor Commented:
Just had the problem again with the mouse being slow. Also that task manager open at the same time and CPU is between 2-5% the whole time
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nobusCommented:
you couyld check if using 1/2 of the open windows make a difference
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GerhardpetAuthor Commented:
No it makes no difference. Like I said I can reboot the computer it starts even if I only a few windows open
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nobusCommented:
>>  I've been having this problem for a while now   <<   how long is a while?
if pretty recent, you can try a system restore to a date it was ok - it may have been caused by an update
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GerhardpetAuthor Commented:
A good 3 months now. I'm very busy and just have not had the time to troubleshoot but it is annoying to the point that I need to do something

I think I replace the mouse about 1 month ago which did not solve the problem.
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nobusCommented:
look if the system restore goes that far back
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GerhardpetAuthor Commented:
No it does not go that far back.

I just upgraded the video driver but that did not help either
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nobusCommented:
try updating the chipset, and mouse driver also
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GerhardpetAuthor Commented:
I have updated all drivers now and no luck. Still on and off I have the problem
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nobusCommented:
assuming the mouse problem is always there, i would try running from a live cd, like:
http://www.ubcd4win.com/                              ubcd  Win
ftp://mirrors.kernel.org/knoppix-dvd/KNOPPIX_V7.0.4bootonly-2012-08-20-EN.iso        Knoppix

another solution is to install the same, or another OS on a spare disk to test the issue, eg ubuntu : www.ubuntu.com
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GerhardpetAuthor Commented:
It is random and does not occur every day. When it happens it usually last for a few minutes and the it is fine again.

I will try with some ubcd utilities
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nobusCommented:
>>  It is random and does not occur every day  <<  doe sit happen with certain programs, or with any?
otherwise "install the same, or another OS on a spare disk " is your best way to troubleshoot
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nobusCommented:
then this is my suggestion, to check where it comes from :  install the same, or another OS on a spare disk
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nobusCommented:
that's a solution, but why not try with another disk, as suggested?  it is rateher cheap,60-80$ for a new one; you can also test with an old one
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GerhardpetAuthor Commented:
That is a large undertaking considering the number of programs I have on my computer.

Perhaps it would be a solution if the problem was predictable but it is not. Now I haven't had the problem for 2 weeks.
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nobusCommented:
You don't have to install evrything - just the OS and drivers, to see where it comes from
and on a new one - you don't have to install them ?
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GerhardpetAuthor Commented:
Did not find a solution for this. I'm giving up on the computer and buying a new one
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