I've been having this problem for a while now where the mouse movement response is slow on and off.
I can reboot the computer and it make no differents. From time to time I notice that Explorer stops responding and then my task bar disappears and come back up when Explorer is restarted.
At first I replaced the mouse with a new one but that did not help. I usually have 10-20 windows open (multiple RDP sessions, Access, Word, Excel, two different ERP applications, Crystal Reports, Chrome, FireFox, IE VMware Workstation, etc...).
Intel Core i7 CPU 870 2.93 GHz
16 GB of Ram
1 TB RAID 0 (2 sata drives)
Any ideas where to start with troubleshooting?