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receiving dns; mail.messaging.microsoft.com Diagnostic-Code: smtp; 550 Requested action not taken: mailbox unavailable

Wondering why I am having this issue with a certain domain sending email.
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Chris H
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Did you have this domain name inside your domain at one time?
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No this is to an external company. Never had this before I started hosting my own email, and obviously their server is exchange based, but not sure. Used mxtools and we are on 2 possible blacklists, but besides that all looks well.
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Chris H
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I am using postfix on this end and can send to anyone except one of our recipient domains. I set up a separate domain.com dns zone in the DNS server to point to the local IP address instead of the external because of mobile workers coming in. Is that going to affect anything if I just use the IP address for my internal users pc's that do not leave the building?
No.