NDR 550 5.5.1 User Unknown for Internal Relay Domain exchange 2003

NDR 550 5.5.1 User Unknown for Internal Relay Domain exchange 2003

Email route happening internally with in the same domain , but some times users are getting   NDR 550 5.5.1 User Unknown  - exchange 2003 environment
BuntyquestAsked:
Who is Participating?
 
Manpreet SIngh KhatraConnect With a Mentor Solutions Architect, Project LeadCommented:
Is this a normal Windows 2003 without any NT servers\Domain ?
How many SMTP connectors do you have and whats the settings on them ?
Do you have any AV or 3rd party softwares on the Server ?

- Rancy
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Manpreet SIngh KhatraSolutions Architect, Project LeadCommented:
Why do you have this Internal relay domain is there some other location domain having this same Domain ?
Is this NDR received by users sending email or some Application ?

- Rancy
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NetfloCommented:
Your question is too vague. You need to provide details on your environment setup, have you recently upgraded or migrated systems?
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BuntyquestAuthor Commented:
Both the mailbox's are in same exchange 2003 server .we didnt upgraded or migrated systems .

Issue happening interminently .

Error:

Original-Envelope-ID: c=US;a=MCI;p=MYDOMAIN ;l=USNJPRIEXG70-130509110719Z-17088
Reporting-MTA: dns; server.MYDOMAIN .com

Final-Recipient: RFC822; PClements@MYDOMAIN.com
Action: failed
Status: 5.1.1
X-Supplementary-Info: <server.MYDOMAIN .com#5.1.1>
X-Display-Name: Username
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