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Exchange down

Applied some security updates and the information store is stuck on starting...
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Alex Young
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lots about losing connection to DC's...
Rebooted it, seems ok, will investigate further..
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Process MAD.EXE (PID=5184). Topology discovery failed, error 0x80040952 (LDAP_LOCAL_ERROR (Client-side internal error or bad LDAP message)). Look up the Lightweight Directory Access Protocol (LDAP) error code specified in the event description. To do this, use Microsoft Knowledge Base article 218185, "Microsoft LDAP Error Codes." Use the information in that article to learn more about the cause and resolution to this error. Use the Ping or PathPing command-line tools to test network connectivity to local domain controllers.
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then
The Mailbox Replication service was unable to determine the list of mailbox databases hosted in the local Active Directory site.
Error: Could not find any available Domain Controller.
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Service MSExchangeMailSubmission. Exchange topology discovery encountered an exception Microsoft.Exchange.Data.Directory.ADTransientException: Could not find any available Domain Controller.
   at Microsoft.Exchange.Data.Directory.ConnectionPoolManager.GetConnection(ConnectionType connectionType, ADObjectId domain, String serverName, Int32 port, NetworkCredential credential)
   at Microsoft.Exchange.Data.Directory.ConnectionPoolManager.GetConnection(ConnectionType connectionType)
   at Microsoft.Exchange.Data.Directory.ADSession.GetConnection(String preferredServer, Boolean isWriteOperation, Boolean isNotifyOperation, String optionalBaseDN, ADObjectId& rootId, ADScope scope)
   at Microsoft.Exchange.Data.Directory.ADSession.GetReadConnection(String preferredServer, String optionalBaseDN, ADObjectId& rootId, ADRawEntry scopeDeteriminingObject)
   at Microsoft.Exchange.Data.Directory.ADSession.Find(ADObjectId rootId, String optionalBaseDN, ADObjectId readId, QueryScope scope, QueryFilter filter, SortBy sortBy, Int32 maxResults, IEnumerable`1 properties, CreateObjectDelegate objectCreator, CreateObjectsDelegate arrayCreator, Boolean includeDeletedObjects)
   at Microsoft.Exchange.Data.Directory.ADSession.Find(ADObjectId rootId, QueryScope scope, QueryFilter filter, SortBy sortBy, Int32 maxResults, IEnumerable`1 properties, CreateObjectDelegate objectCtor, CreateObjectsDelegate arrayCtor)
   at Microsoft.Exchange.Data.Directory.ADSession.Find[TResult](ADObjectId rootId, QueryScope scope, QueryFilter filter, SortBy sortBy, Int32 maxResults, IEnumerable`1 properties)
   at Microsoft.Exchange.Data.Directory.SystemConfiguration.ADSystemConfigurationSession.Find[TResult](ADObjectId rootId, QueryScope scope, QueryFilter filter, SortBy sortBy, Int32 maxResults)
   at Microsoft.Exchange.Data.Directory.SystemConfiguration.ADSystemConfigurationSession.FindServerByFqdn(String serverFqdn)
   at Microsoft.Exchange.Data.Directory.SystemConfiguration.ADSystemConfigurationSession.FindLocalServer()
   at Microsoft.Exchange.Data.ApplicationLogic.PickerServerList.LoadFromAD(PickerServerList oldServers)
   at Microsoft.Exchange.Data.ApplicationLogic.ADConfigurationLoader`2.<>c__DisplayClass1.<ReadConfiguration>b__0()
   at Microsoft.Exchange.Data.Directory.ADNotificationAdapter.RunADOperation(ADOperation adOperation, Int32 retryCount)
   at Microsoft.Exchange.Data.Directory.ADNotificationAdapter.TryRunADOperation(ADOperation adOperation, Int32 retryCount) when trying to load topology information.