Exchange 2003 Outbound Queueing EVENT ID 4006

I am getting some emails stuck in the queue now and they are all going to external users and number or recipients on the email message and there is a warning in the event log from the exchange server:

 Event Type:      Warning
Event Source:      MSExchangeTransport
Event Category:      Connection Manager
Event ID:      4006
Date:            6/10/2013
Time:            2:47:29 PM
User:            N/A
Computer:      Computer
Description:
Message delivery to the host 'IP ADDRESS' failed while delivering to the remote domain  'DNS' for the following reason: Unable to open the message for delivery.


For more information, see Help and Support Center at http://go.microsoft.com/fwlink/events.asp.
Data:
0000: e0 02 04 c0               à..À
hinduguyAsked:
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hinduguyAuthor Commented:
I have looked over it, and my SMTP virtual server and SMTP Connector is setup correctly.
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AmitIT ArchitectCommented:
Try this, stop and restart the SMTP Virtual server via ESM, check if that works, if not then stop it and create one more SMTP Virtual and test again.
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hinduguyAuthor Commented:
I rebooted the server last night and I will keep an eye on it.
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hinduguyAuthor Commented:
Rebooting the system seem to have resloved the issue.
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