I have noticed a few small issues with MS Office 2010 on XenApp 6.5 Published desktops.
All of our users run published desktops. Office 2010 is a standard application for all users, so it is installed locally on each Published Desktop host Server (server 2008 R2).
When Outlook is open, as soon as a new email arrives, the notification window will appear above the taskbar, but when it does, the users desktop session slows to a painful speed until the window disappears. It's only a few seconds, but if you start trying to type/move the mouse while the window is appearing/disappearing, you end up just making it take longer to disappear.
Also when attempting to move the window around the display for any of the MS office applications, they also move very slowly across the screen compared to trying to move the window for anything else (eg a browser window, windows explorer window). Anything other than the MS office apps move around the screen as quick as if it was on your local machine.
The policy to only show only the outline of the window is enabled.