OUTLOOK anywhere error RPC_S_server_Unavailiable (0x6ba)

My setup is exchange 2007 on server 2003
Remote clients cannot setup OUTLOOK anywhere session. They get a message about the Exchange server being unavailable when they configure outlook anywhere.
If I run the exchange connectivity tool it passes autodiscover test but fails the RPC/HTTP test at the last step with message RPC_S_server_unavailable (ox6ba) on port 6004. There is lots of information about this error and server2008/IPv6 but I am using server2003 IPv4.
Can anyone give me some pointers on how to fix this one.

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mlatzAuthor Commented:
I checked the Virtual Directory permissions and found they where not as expected. Changed them to what they should have been and rebooted the email server. The reboot was necessary. An IIS reset was not enough. This fixed my problem
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