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Viankus

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PC Clean up

What shuld bne the proper way to get rid of malware,spyware , etc besides having a antivus ( McAee) to mantain a good performance of my PC
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I normally create one vm machine, download whatever you want, use it and then get rid of VM machine. Safe and easy.
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The best combinations that I have suggested to one company I worked at was both Avast and Kaspersky - they went with Avast and SuperAntiSpyware.  

MalwareBytes is great but I feel the definitions for SAS are better.  With SAS and Avast within 2 years I think we had 2 high-level infections.
For (infected with) rootkits:

(1) TDSSKiller.

(2) Malwarebytes Anti-Rootkit (Beta).

(3) Avast antirootkit ("aswMBR.exe").

(4) ComboFix.

In that oder.
Read through these EE Articles for some basic ideas:

https://www.experts-exchange.com/A_1940.html Basic Malware Troubleshooting
https://www.experts-exchange.com/A_4922.html Rogue-Killer-What-a-great-name
https://www.experts-exchange.com/A_5124.html Stop-the-Bleeding-First-Aid-for-Malware
https://www.experts-exchange.com/A_6650.html Malware Fighting – Best Practices
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tmoore1962

Wiseapps Disk and registry cleaning apps are also good choices to help keep system clean and performing well run disk cleaner either before or after removing all malware (before will remove all the temp files and other junk so the malware tools don't have to scan them)  Use the backup function of the registry cleaner before cleaning  / defragging registry just in case.
For systems that are real bad make a Kaspersky rescue cd / usb drive and boot from it to make sure the rootkits and malware have been removed.
Beware of running any cleaning app that cleans the temp directory if you think you have been infected.  As younghv has pointed out some of the newer malware move necessary files to the temp directory.