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User Mailbox size concerns

I ran a PS command to see the size of all users mailboxes on my exchange server. I have plenty of space on my server. My concern is what complications can occur because Ive read mixed things about this topic. Some people say if you have the space exchange 2010 will run good. Others say anything bigger then 4GB is to big and risky. what do you all think about this?

The CEO is the biggest by far at

TotalItemSize    16.19 GB (17,387,673,057 bytes)                                          
ItemCount        131056

The rest of the network looks like this

3.571 GB (3,833,948,501 bytes)
6.13 GB (6,581,965,406 bytes)
6.369 GB (6,838,341,685 bytes)
3.079 GB (3,305,837,155 bytes)
1.807 GB (1,940,618,116 bytes)
6.413 GB (6,885,538,543 bytes)
2.704 GB (2,903,204,416 bytes)
4.382 GB (4,705,533,834 bytes)
3.794 GB (4,074,303,015 bytes)
7.036 GB (7,555,263,700 bytes)
6.8 GB (7,301,643,059 bytes)

The others are in the MB
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Joseph Daly
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It depends on your exchange configuration. Is this a single server, multiple servers, DAG?

Are all of these mailboxes in one DB?

If you are runnning a single mailbox server with no DAG then I believe MS reccomends the maximum size of a DB be no larger than 100gb
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This is one hyper-v exchnage server running the typical active directory no dag. dag is multiple database servers combined? If so than we don't have dag.  Yes one DB
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Jon Brelie
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this is not a DAG server.  Not sure if the same rules apply.
my db is about 120gb
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thank you.  Now regarding single user mailboxes and item counts. Is there a limit or 2010 can pretty much handle any user capacity?
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I've been searching for the guidelines regarding the outlook versions and the recommended OST files.  Anyone know where I might find this?
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thank you all for the info