Backup Exec 2010 R3 Jobs Stuck in Queue, or failing

These backups are backup to disk. The daily jobs (incremental) stay in the queue. When they are in the queue, I can open to the Backup Exec Debug Monitor to recieve the following messages:

BESERVER: [09/23/13 11:08:00] [8916]     "Cluster" key does not appear to be present in the registry
BESERVER: [09/23/13 11:08:00] [8916]     Failed to open Microsoft cluster ()
BESERVER: [09/23/13 11:08:00] [8916]     VCS cluster keys do not appear to be present in the registry
BESERVER: [09/23/13 11:08:00] [8916]     Failed to open VCS cluster ()

The weekly backups that are the basis for the daily incremental runs, but it fails with the following errors:

Job ended: Saturday, September 21, 2013 at 6:56:11 AM
Completed status: Failed
Final Error: 0xe000810d - Physical Volume Library Media not found.
Final Error Category: Backup Media Errors

For additional information regarding this error refer to V-79-57344-33037

I can access the UNC path that the backup files are stored in, there's plenty of space there as well, I even set the permissions to allow full access to all users, still no change. Any ideas?
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Check the overwrite/append settings for the media set the usb drive folders are in.
Rodney BarnhardtServer AdministratorCommented:
As far as the "cluster key" error, are you backing u Exchange on this system? If so, try removing and re installing the Exchange agent. Also, check the accounts the services are running under. They should be as follows:

Backup Exec Agent Browser= domain service account
Device and Media Service = domain service account
Job Engine =  domain service account
Remote Agent for Windows = local system account (if this is running under a DSA, then that may be the "cluser key" error also.
Server = domain service account
nappy_dThere are a 1000 ways to skin the technology cat.Commented:
Are trying to dedupe your backups, B2D or straight to tape?

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Jonathan3Author Commented:
Sorry for the lack of response folks; this was a bad NAS that we're rebuilding. Thanks for the suggestions.
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