We run Windows SBS 2003 in a network of about 20 clients. Most of the clients are running Windows XP Pro; a few of them now are running Windows 7.
Lots of malware gets through the AV app... surprise! surprise! I have been using Spybot Search and Destroy, Malwarebytes Antimalware, and SuperAntispyware. I also use Combofix at times for the hard cases. These tools have been around a long time. Are there better ones available now? What is the best procedure these days for getting rid of malware?