Users various license keys failing- possible virus?

Had a user one day, said her PC said her Quark software was expired and needed to re-enter code (trial done) (she has full, paid version)
Soon after, her Adobe XI pro did the same.
Yesterday, her Office said similar

I think there is some sort of virus deleting her keys
If I enter the keys, and she reboots--it *seems* to kill the licenses again---although I have not fully verified this.

Obviously this is a problem..

I have run malwarebytes, MS AV and even Combofix...nothing has found anything ...that fixed it anyway...  If anyone has a good (prefer free) AV/AMW/cleaning software...let me know

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Thomas Zucker-ScharffSolution GuideCommented:
Are you sure these are valid key requests?  They might be fake dialogs to get you to put in the keys so a keylogger can steal them.  Not to be alarmist or anything, but I would first run Malwarebytes Chameleon on the machine following the instructions in the forum post below.

You might also want to do a rootkit scan with at least 3 of the free antirootkit apps reviewed in this article:

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DCratsAuthor Commented:
going to rebuild
Thomas Zucker-ScharffSolution GuideCommented:
Use Darik's boot and nuke first (dban). Backup then autonuke.
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