Windows Server Backup Failing Server 2008 Standard R2

Windows Server 2008 R2 Standard on a physical box.

Backups scheduled through Windows Server Backup have been failing for a few weeks now, with Event ID 521. Details below:

"Backup started at '11/8/2013 1:22:45 AM' failed as Volume Shadow copy operation failed for backup volumes with following error code '2147943578'. Please rerun backup once issue is resolved."

More Details from Event Log:

"- System

  - Provider

   [ Name]  Microsoft-Windows-Backup
   [ Guid]  {1db28f2e-8f80-4027-8c5a-a11f7f10f62d}
   EventID 521
   Version 0
   Level 2
   Task 0
   Opcode 0
   Keywords 0x8000000000000000
  - TimeCreated

   [ SystemTime]  2013-11-08T01:22:49.729Z
   EventRecordID 1115653
  - Execution

   [ ProcessID]  8432
   [ ThreadID]  6692
   Channel Application
   Computer FRSRVR.foresight.local
  - Security

   [ UserID]  S-1-5-18

- EventData

  BackupTime 2013-11-08T01:22:45.252Z
  ErrorCode 2147943578
  ErrorMessage %%2147943578 "

Steps already taken:
Installed a new ext hdd for backup target and reconfigured backup job accordingly
Removed WSB feature and Re-added

The same exact error persists after this. Any advice would be greatly appreciated.
Who is Participating?
MHMAdminsConnect With a Mentor Commented:
I would start by going into elevated command prompt on the server you are backing up, then run: Vssadmin Delete Shadows and try to run the backup again and see if it still fails with VSS error.
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