Error Message: Access is denied. (Exception from HRESULT: 0x80070005 (E_ACCESSDENIED))

Hello,

My users are receiving the above errors when attempting to access a web application. Below is the log error. The server is running 2008R2 and we have removed and added it from the domain and added explicit privileges at the file system level for all the users to have read/execute permissions on the file but still receive the error. It is intermittent and will come and go without indication.

Error in: http://phoenix/metastorm/default.aspx
Error Message: Access is denied. (Exception from HRESULT: 0x80070005 (E_ACCESSDENIED))
Stack Trace:    at System.ConfigServer.RunParser(IConfigHandler factory, String fileName)
   at System.ConfigTreeParser.Parse(String fileName, String configPath, Boolean skipSecurityStuff)
   at System.ConfigTreeParser.Parse(String fileName, String configPath)
   at System.Security.Cryptography.CryptoConfig.InitializeConfigInfo()
   at System.Security.Cryptography.CryptoConfig.CreateFromName(String name, Object[] args)
   at System.Security.Cryptography.PasswordDeriveBytes.set_HashName(String value)
   at System.Security.Cryptography.PasswordDeriveBytes..ctor(String strPassword, Byte[] rgbSalt, CspParameters cspParams)
   at Metastorm.Web.Common.CryptoAlgorithms.Encrypt(String clearText)
   at Metastorm.Web.Security.BpmIdentity.SaveSessionToCookie()
   at Metastorm.Web.Security.BpmMembershipProvider.ValidateWindowsUser()
   at Metastorm.Web.Security.BpmAuthenticationModule.OnAuthenticateRequest(Object source, EventArgs eventArgs)
   at System.Web.HttpApplication.SyncEventExecutionStep.System.Web.HttpApplication.IExecutionStep.Execute()
   at System.Web.HttpApplication.ExecuteStep(IExecutionStep step, Boolean& completedSynchronously)