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Microsoft IIS SMTP Virtual Server Errors

Hi Experts,

I have a Windows Server 2008 R2 running the SMTP service/Virtual SMTP server.  I point many different applications to this to send alerts/notifications, etc and it has grown to become a critical service.  I haven't configured the service to use another relay at this point.

Recently, mail has really been delayed.  I enabled logging through the IIS 6 manager and I'm seeing messages like this.  I've checked with the email provider at the other end and there are no issues.  I have mostly defaults in the Virtual SMTP settings.  Any thoughts?  Since we rely on this service so much is it worth looking into another solution at this point?  I've also tried sending messages to other domains with similar results.

OutboundConnectionResponse SMTPSVC1 SERVER-VS4 - 25 - - 220+******************************************************** 0 0 60 0 296 SMTP - - - -
OutboundConnectionCommand SMTPSVC1 SERVER-VS4 - 25 EHLO - SERVER-VS4.SERVERmedical.local 0 0 4 0 312 SMTP - - - -
OutboundConnectionResponse SMTPSVC1 SERVER-VS4 - 25 - - 250-inbound94.exchangedefender.com+Hello+static-XX-YY-154-82xxx.xxx.xxxx.net+[XX.YY.154.82],+pleased+to+meet+you 0 0 122 0 390 SMTP - - - -
OutboundConnectionCommand SMTPSVC1 SERVER-VS4 - 25 MAIL - FROM:<noreply@SERVERmedical.com> 0 0 4 0 390 SMTP - - - -
OutboundConnectionResponse SMTPSVC1 SERVER-VS4 - 25 - - 250+2.1.0+<noreply@SERVERmedical.com>...+Sender+ok 0 0 51 0 686 SMTP - - - -
OutboundConnectionCommand SMTPSVC1 SERVER-VS4 - 25 RCPT - TO:<sgendron@SERVERmedical.com> 0 0 4 0 686 SMTP - - - -
OutboundConnectionResponse SMTPSVC1 SERVER-VS4 - 25 - - 250+2.1.5+<sgendron@SERVERmedical.com>...+Recipient+ok 0 0 55 0 811 SMTP - - - -
OutboundConnectionCommand SMTPSVC1 SERVER-VS4 - 25 DATA - - 0 0 4 0 811 SMTP - - - -
OutboundConnectionResponse SMTPSVC1 SERVER-VS4 - 25 - - 354+Start+mail+input;+end+with+<CRLF>.<CRLF> 0 0 44 0 811 SMTP - - - -
OutboundConnectionResponse SMTPSVC1 SERVER-VS4 - 25 - - 451+Please+try+again+later 0 0 26 0 1123 SMTP - - - -

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Exchange is the server side of a collaborative application product that is part of the Microsoft Server infrastructure. Exchange's major features include email, calendaring, contacts and tasks, support for mobile and web-based access to information, and support for data storage.

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