Most internal users are experiencing the issue of not being able to set Out Of Office replies via Outlook, going against Exchange 2010. All users are internal to the network and setting does work from OWA. The error is the same on all workstations:
Your automatic reply settings cannot be displayed because the server is currently unavailable. Try again later.
I have verified Outlook Connectivity via right-click Connection Status and have also tested the autoconfiguration without error ( right-click Outlook, Test Email Autoconfiguration ). The Log tab shows Autodiscover is found and succeeded. In the results tab, I can take the URL for OOF and successfully browse to it.
I have the latest Office service pack and all services are running on the server.
I have browsed dozens of articles and am unable to find the answer. Most indicate it is an autodiscover issue, but autodiscovery is correctly functioning.