Temp directory access denied in Mozilla Firefox

Over the past couple of days a few users have had problems downloading from Firefox.  It also started happening with me yesterday and today.  When trying to download something (Dell drivers for example), it gives the following error:

Downloading C:\Users\myusername\AppData\Local\Temp
C:\Users\myusername\AppData\Local\Temp could not be saved, because you cannot change the contents of that folder.

Change the folder properties and try again, or try saving in a different location.

I have Firefox set to ask me where to download files, but it doesn't ask, it just gives this error.  Even if I set a specific folder to download to, it still gives this error.  I then go to Internet Explorer and downloads work just fine.  What is going on with this?  Did Firefox change something?
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jbobstConnect With a Mentor Author Commented:
Upon further inquiry, I found out the McAfee policies were changed over the weekend and this is the cause of my issue.  Thank you all for the help.
Hi jbobst,
something has happened with your permissions to Temp folder.
Please try to run Firefox as an Administrator, by right clicking it and Run as Administrator.
See if it can save the download files now.
jbobstAuthor Commented:
Same problem even running firefox as administrator.  I can go directly to my temp folder and add/delete/modify files with no problem.  I don't think this is a real permissions issue.
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You can try to change the default Download location.
Mozilla Options
Than, as a last tool, unistall it and install it again. Please do save your bookmarks before installing it.
jbobstAuthor Commented:
I did change my locations and it still gives me the error, even though the location is the downloads folder, not the temp folder.  I'll try a re-install, but a few people in my company have all had this problem over the past couple of days.
KrokodiliConnect With a Mentor Commented:
Maybe your System Admin has put new policy changes on the domain, not allowing Mozilla to download files.
jbobstAuthor Commented:
I'll check into that.  I am one of the system admins, so I am pretty sure that didn't happen, but maybe someone else did something like that.
Pramod UbheConnect With a Mentor Commented:
i would troubleshoot it in this order -

turn off UAC and check if that helps
login with diff. account to see if it is user profile specific
re-install firefox to see if it is specific to firefox
try with a diff. browser (IE/Chrome)

also you can try disabling local firewall/antivirus.
McKnifeConnect With a Mentor Commented:
An analytic approach would be to have the freeware monitoring program procmon monitor what is happening. Procmon sees what the file system is telling firefox. Please see if procmon records "access denied" results, if so which. And then check the ACLs on those files/folers.
jbobstAuthor Commented:
Found out it was an internal policy change
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