Updating multiple columns in a single update transaction

I have a table with many columns.  Some have a default value of 0 and need to set it to null (after removing the constraint of course).

Rather than have multiple update statements that look like this:

update table1 set column1 = null where column1 = 0
update table1 set column2 = null where column2 = 0

Is there a way to wrap these up into a single update statement or transaction with multiple where clauses?
ccleebeltAsked:
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chaauConnect With a Mentor Commented:
I would perhaps add a WHERE clause to restrict the number of scanned rows, like this:
update table1 set
  column1 = case when column1 = 0 then null else column1 end
  , column2 = case when column2 = 0 then null else column2 end 
WHERE column1 = 0 OR column2 = 0

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Dale BurrellDirectorCommented:
update table1 set
  column1 = case when column1 = 0 then null else column1 end
  , column2 = case when column2 = 0 then null else column2 end
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