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Microsoft Outlook can not open attachments - intermittent

Hi we recently upgraded our Exchange Server to 2013.

Since then users on Outlook 2010 and Outlook 2007 are receiving the following message when trying to open an word or excel attachment:

Cannot open file: C:\\users\dianaw\AppData\Local\Microsoft\Windows\Temporary Internet Files\Content....The file may not exist, you may not have permission to open it, or it may be open in another program. Right-click the folder that contains the file, and then click Properties to check your permissions for the folder.

The attachment will eventually open after several tries.

I have tried the following:

I have checked the permissions on the C:\\users\dianaw\AppData\Local\Microsoft\Windows folder

I have looked at cleaning out the Temporary Outlook Files folder

I have modified trusted locations in word and excel to allow sub folders.

I have tried to open outlook in safe mode in case it was an add-in that was causing the problem.

Any suggestions as users are getting frustrated.

Thanks
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yaminz66
Asked:
yaminz66
1 Solution
 
Ravi Kumar AtreyServer Administrator- Server Security, Backup and ManagementCommented:
Check the below link and follow the given suggestions::

http://store.lucion.com/s.nl/ctype.KB/it.I/id.69/KB.307857/.f


Hope it would solve the issue, but as per my experience, It could be either locking issue or corruption of outlook.

Just follow the suggestions given in link.

Thanks,
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yaminz66Author Commented:
Hi Ravi

Thanks for your suggestion. The link is about opening Outlook MSG file, the issue I have is with Word and Excel Attachments which intermittently open.
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Md. MojahidCommented:
Have you try to open outlook once in safe mode.
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yaminz66Author Commented:
Hi MDMOJAHID

Yes tried opening in safe mode to disable add-ins.

Still same issue with attachments.

Thanks

Mohammed
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swgitCommented:
have you tried running office diagnostics from the "help" menu, or repair from uninstall or change a program?
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yaminz66Author Commented:
I have uninstalled ESET Anti Virus and this seems to have resolved it. I guess launching outlook in safe mode does not disable Eset interference!

I have Panda running which does not interfere with Outlook.

Thanks everyone for your suggestions.
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yaminz66Author Commented:
ESET has a an add-in to Outlook and I guess it was accessing the attachment and thus preventing the user as the error message states the file may be in use.

Solutions online suggested launching outlook in safe mode but this obviously did not stop ESET from interfering with the attachment.

Hope that helps.
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