Symantec Endpoint Protection 12.1

Good practices from Symantec is useful material.

Always good to run a quick report from Symantec Endpoint Protection Manager that provides a list of the Symantec Endpoint Protection software versions that are installed on the clients and Symantec Endpoint Protection Manager servers in your network. This is to ascertain the current state and connectivity to the clients.
http://www.symantec.com/business/support/index?page=content&id=HOWTO63841

Specifically for WAN link i suggest checking out the best practices when deploying Symantec Endpoint Protection client package over saturated 64k WAN links.
http://www.symantec.com/business/support/index?page=content&id=TECH132352

To maintain latest signature, pls see below
http://www.symantec.com/business/support/index?page=content&id=TECH102467

Also there is other to check out if time permit ...

LIVEUPDATE, SEPM & GUP UPDATES:

Best Practices for Central Deployment and Management of Symantec Endpoint Protection (SEP) in a Workgroup environment.
http://www.symantec.com/docs/TECH91679

Best Practices with Symantec Endpoint Protection (SEP) Group Update Providers (GUP).
http://www.symantec.com/docs/TECH93813

Best practices for upgrading to the latest version of Symantec Endpoint Protection 12.1.x
http://www.symantec.com/business/support/index?page=content&id=TECH163700


SECURITY & THREATS:

Security Best Practice Recommendations.
http://www.symantec.com/docs/TECH91705

Best practices for responding to active threats on a network.
http://www.symantec.com/docs/TECH122466

Security Response recommendations for Symantec Endpoint Protection settings.
http://www.symantec.com/docs/TECH122943

Best Practice when Symantec Endpoint Protection or Symantec AntiVirus is Detecting a File that is Believed to be Safe.
http://www.symantec.com/docs/TECH98360

Best practices regarding Intrusion Prevention System technology.
http://www.symantec.com/docs/TECH95347