Huge Buffer Misses on Cisco 3550-12G switch

I am seeing buffer misses on my Cisco 3550-12G.  These are not just small, medium, or big buffer misses, they are Huge Buffer misses.  There has been reported slowness on the network and this is the only area on the network at all where I see red flags.  What can I do about the huge buffer misses?  I have over 200 huge buffer misses this hour.