I have a client who was infected with PUPs. I believe I got rid of them with MBAM, SAS, RogueKiller, Hitman Pro, AdwCleaner and JRT.
Things seem to be working well except for Internet Explorer. It will open but almost nothing else works. I can not search or click on anything except for occasionally tools and the gear settings tool. I saw Internet Explorer (Enable DEP), (first time I've seen that). I removed it from Programs. I reset IE, no difference. I uninstalled the IE update and re-installed IE..no difference. Any ideas??