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Internet Explorer not functioning

Hello,
I have a client who was infected with PUPs.  I believe I got rid of them with MBAM, SAS, RogueKiller, Hitman Pro, AdwCleaner and JRT.

Things seem to be working well except for Internet Explorer.  It will open but almost nothing else works.  I can not search or click on anything except for occasionally tools and the gear settings tool.  I saw Internet Explorer (Enable DEP), (first time I've seen that).  I removed it from Programs.  I reset IE, no difference.  I uninstalled the IE update and re-installed IE..no difference.  Any ideas??
Mags
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aadih
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Thanks...I should have access to her computer tomorrow.  I will post you up.
Mags
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Thomas Zucker-Scharff I totally agree...Rogue Killer did it for me!
Yes I recommend RK and MBAM for most users.  This usually takes care of the problem.  I have one user that now says his homepage is set to Tigzy's homepage (i believe he has it set to bring up the last used tab instead of a home address or a blank, but he is a little confused), but otherwise I have never had a problem.

BTW, Mags haven't seen you around in a while - how have you been?
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Thomas  I've been great!  Still working with mainly seniors so I know what you mean about being "a little confused"!  Haven't seen you on my posts recently either...maybe different area...your help is always welcome!

I hope all is well with you and that you have an amazing 2014!!
Thanks!  My guy, although not quite a senior (depending on your definition - he is over 65) is generally computer illiterate, but also my boss.
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Ran sfc /scannow 3 times...no issues.  I was glad I ran this as this computer had been upgraded from XP!

IE still would not work...did a little searching and came up with the suggestion to try running IE as administrator which did the trick!  I set it to always run as administrator.  Should I have any other concerns?
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Did you look into the event manager to see what messages you were seeing when IE was not working? Permission problem? Did it run okay from the safe mode? Please try your best to debug.

Or as Thinkpads_User suggests, run a Windows repair install.
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I was afraid of that.   She was only infected by some PUPs...do you need to see the logs?

I'll have to get her computer if she can put more money into it.  Thanks!
Mags
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I don't think she has any more money to put in this computer...it is very old.  Other than simply using Chrome or Firefox any other foreseeable issues?  I believe her computer is clean from Malware.
Thanks,
Mags
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@MagsMcKinley14 - Thanks and I was happy to help.

.... Thinkpads_User