Our Exchange Server 2010 is giving out users a lot of the "Outlook is trying to retrieve data from the Microsoft Exchange server". Its running on Server 2008 R2 SP1 with a Xeon E5-2440, 32GB RAM, and a RAID 5 array w/ 15K SAS drives. The database is getting large - about 275GB. What would cause this to happen all at once? Would separating half the users into another database help? I've got 3 databases now, but 2 are relatively small. HELP!