My client has a Vista computer running Outlook 2007. All of a sudden, it is consistently failing to respond. I ran SCANPST a couple of times to clear up some errors that were identified. Ran an additional scan to confirm that errors ere resolved. Outlook will function in safe mode. Disabled Norton 360 firewall and antivirus to see if that might resolve the problem, but it did not. Also ran Office Diagnostics, but no problems identified. Disabled all add-ins possible. Even though logged in to an administrator account, could not disable all add-ins. This configuration has been running fine for several years. Yes, it's definitely time for a new computer (recommended that several months ago), but need to breathe a little life into this one for the time being. Thanks for ideas to help resolve this issue!