sent email in outbox

I just migrated to exchange 2013, and ever since, I have some clients not able to send email.
Some clients work fine, but some, when sending email, the emails just sit in their outbox.

The clients are outlook 2010, with SP1, and the rollup needed for exchange 2013.

Not sure what to do to resolve this issue?
DanNetwork EngineerAsked:
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SeanConnect With a Mentor System EngineerCommented:
Have you tried to recreate their outlook profile? What steps have you taken so far?
DanNetwork EngineerAuthor Commented:
Yes, I have tried the following:

1. deleted the OST file, and mail will work for a few hours, but then stops again.
2. I have deleted the outlook profile, but still doesn't work
3. I have upgraded the client to office 2013 pro, still doesn't work.

Not sure what else to do.
suriyaehnopConnect With a Mentor Commented:
Are effected user able to send an email via Outlook Web App?
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DanNetwork EngineerAuthor Commented:
Yes, everything works good on the outlook web app
SeanSystem EngineerCommented:
Antivirus doing something with the OST?
DanNetwork EngineerAuthor Commented:
no, it's not.
DanNetwork EngineerAuthor Commented:
It's been only happening on a few clients, I've either updated them to office 2013 and reset their outlook profile and so far so good.
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