Recently Documents have been opening extremely slowly on computers that are on the immediate network from the SharePoint servers. It is happening in Office 2010 and Office 2013. At times it can be about 30 seconds after confirming to open the document before it launches the appropriate application. Interesting to note, a computer that is not on the domain but is accessing via VPN is able to open the same documents instantaneously. Documents are coming from a document library and are only Office files. The problem does not seem to occur on .PDF or Image files that are held in the same library.
•Attempted Fiddler to look into authentication issues. - None found
•Ran Developer tools on IE11 to try to narrow down a particular script that hangs - None Found
•Disabled McAfee on both server and workstation to rule out on access scanning causing issues - No Resolution
•Updated Content Databases and installed latest hotfixes on SharePoint Farm
•Verified latest version of Office 2010 and Office 2013 are installed
•Lowered the settings for Office Upload Tool to removing caching and duplicate files being held.
•Unchecked "Auto Detect Proxy" in IE
Any assistance or ideas would be great, I've run out of ideas.