I just recently migrated a 10-node cluster over to a new datacenter using a brand new database. I finished up most of the vCenter cluster configuration manually, but we have a ton of VMs and Template folders and many VMs that need to be assigned to resource pools. I also plan to eventually upgrade the hosts from scratch, which will entail also rebuilding the vSwitches.
We don't run Enterprise Plus just yet, so Host profiles and vDS would be the obvious place to start. But I believe a kick starter script during the install may work if it can also do vSwitch configuration (which I don't think is the case). And for the resource pools and VM folders, there isn't a way to do bulk adds instead of manually selecting one VM at a time and moving them to the appropriate pool/folder?