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AD Profile and File server

what is the key advantage on going with AD profile in 2008 server R2 OS . we need to have  NAS file server also get in to the AD environment  with DFS  ? I am not too sure weather we can have all 3  or AD user with AD with DFS implement the such a better.
2 Solutions
As far as I know you don't get very special benefits with 2008 R2 roaming profiles as compared to previous version

Roaming profile compatibilityCheck below article for more information

DFS is not a supported on NAS storage if its mapped as a IP based network storage
DFS is windows technology and you have to have windows native drives \ logical drives from storage in order to work \ setup DFS

If NAS storage is mapped as LUN (logical drive on windows server), you can setup DFS

If you have IP based storage (NAS), then you can probably set snap mirror kind of storage vendor specific technology to setup replication between TWO sites, however note that this kind of replication is one way and manual intervention is required to make it reverse

If you have NAS mapped as a LUN (logical drive) on multiple servers, you can use DFS for creating DFS redundant name space and replica.
This replica will replicate bi-directional

Check below posts for more information

Not quite easy to understand your question. I will try.
I assume you mean romaing profiles, means the profile of each user is stored on a DC rather than on th elocal machine.
The advantage is, that you can logon on any machine and get your used desktop, your files etc. Also backing up the profiles is easier as they reside on one single place and you can change profiles (permissions assumed) from a central place.

The disadvantage is, that profiles has to be replicated and this takes a bit longer than a local profile.

DFS is a different topic. Is is used to replicate files and folders onto a second store, either to have them redundant or to speed up distributed environments (you replicate content from one location to another). DFS can be setup on folder level an gives a client possibly a second access point to access the files.

To use DFS in combination with roaming user profiles is an option, but has to be handled with care. As DFS syncs with a little bit time delay, it may happen, that essential files ore store on one node, but not on the other. THis can produce some issues, if the client takes the other node and essential files in the proile are not already replicated. As the client usually holds a copy of the reoaming profile, you can splitt the roaming profile into the essential profile files and the user files (i.e. my documents) so that the user files are seperated from the other profile files. This way you can make sure, that i.e the user profile files are all the times accessed from one defined locations while the documents are distributed. Also some applications do not really like DFS, i.e. Lotus notes produces a lot of traffic as a lot of small files are written into the profile and this produces heavy replication traffic.

Where you locate the profiles and user documents depends from your environment. To provide fast logon with roaming profiles, you should locate the essential files on a fast storage. Even you should make sure, that this storage is hughly available. If your NAS an provide it, feel free to use it.
As DFS has a primar target (dependend how your configure the DFS), you can put your essential profile files on a local disc, the user documents on the NAS, and over cross the other side as a second target.

User profiles can be configured with domain policies, there you configure your targets for the user profile content. And inside the DFS configuration, you can determine, from where to where the files are replicating and how the clients access it.

Hope I hit your questions.
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