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Changing Program Files permissions in Windows 7

Hello Experts!  I need to add some different permissions and change some permissions on a Windows 7 Pro PC in the Program Files x86 directory.  Every time I attempt this Windows security prevents this change from happening.  I am logged on as the domain administrator and I have turned off User Account Control.  What else needs to be done to change the permissions?  Please advise.  Thanks!
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submarinerssbn731
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submarinerssbn731
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jcimarronCommented:
submarinerssbn731--
You may have to take ownership as well.
http://www.addictivetips.com/windows-tips/windows-7-access-denied-permission-ownership/
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submarinerssbn731Author Commented:
Thanks!  Great answer!
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jcimarronCommented:
submarinerssbn731----
You are most welcome!
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