PASV - 425 IIS7 FTP 7.5 issue

So here is my thing. Nothing has changed in my environment.  Nothing.  All of the sudden 3 ports in my Passive range have stopped working.  I use 50000-50300.  So when the connection uses all of the ports and flips back around to the beginning few, it fails with a PASV - 425 error in the FTP log.  This only happens with ports 50000-50002.  So approx 30 of the 1500 files fail.  Talk about needle in a haystack.  Anyone come across this in the past?  I know its rather vague, but its crazy.  I've run wiresharks, continuous netstat -anp tcp commands and pretty much anything else i could think of.  I actually think i've been looking at it too long.  Any help would be GREATLY appreciated!!!!