What network apps are resilient to bad latency? What network apps aren't?

Are there apps that utilize the internet that are especially resilient to bad network latency? I'd hazard a guess that bad-latency resilience is a function of the application (ex. Chrome or Safari) as opposed to the protocol (ex. HTTP), but I could be completely wrong.  

Conversely, are there apps that utilize the internet that are especially vulnerable to bad network latency? For example, I've heard that some flavors of VPN simply croak when network latency goes up. (Feel free to correct me if I'm wrong.)
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In my opinion (but just my 2 cents) latency only is an issue when using SBC kind of tools because it will feel slow, or when you are gaming offcourse. But even when having a very high latency you will still have network connection. I don't believe any VPN connector will have an issue with latency. It will however have issues with a bad connection, that does indeed give issues with VPN clients or database driven applications

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