Using Application Packager before deployment

In SCCM 2012 when deploying an Application to end users, does the Application need to be prepared by sort of an Application packager ? I thought  we just need to  use the MSI file of the APP and deploy it...just like when deploying an APP through GPO.

Another thing is if the Application  already exists (old version), and you want to uninstall it during the install of the new version, how can this be achieved ?

Any help will be very much appreciated .

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Cliff GaliherCommented:
Sometimes you need to customize how the app installs, even with an MSI. Packagers can create .mst files that allow customized installs without modifying the MSI.

SCCM can remove programs as well. MSI installs usually support this natively. Older .exe will require a custom uninstall package to kick off the .exe with the proper flags.

Since each app is unique, it is tough to be more specific right now.

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